Custom Peptides
Cayman Chemical DIosArgtrIfluoroACTAte sa 10mg
A steroid-based cationic lipid; forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio ≥4; facilitates transfection of plasmid DNA into H1299 and HeLa cells; has been used, coupled to DOPE, to bind siRNA and plasmid DNA to form cationic lipid nanoparticles for intracellular transport
Cayman Chemical TC 2559fumarate 10mg
A partial agonist for α4β2 subunit-containing nAChRs (EC50 = 0.18 µM); selective for α4β2 over α2β4, α4β4, α3β4, α3β2, and α7 subunit-containing nAChRs (EC50s = 14, 12.5, >30, >100, and >100 µM, respectively); increases dopamine cell firing in the rat VTA in vitro; enhances inhibitory synaptic transmission in dorsal horn neurons via α4β2 subunit-containing nAChRs; reduces formalin-induced paw-licking time in mice at 3 and 10 mg/kg; reverses scopolamine-induced cognitive deficits in rats in a step-through passive avoidance test at 3 and 6 µmol/kg
Cayman Chemical SynthetIc CalcItrIol 10mg
An agonist of the vitamin D3 receptor and active metabolite of vitamin D3; binds to the vitamin D3 receptor (Kd = 16 pM) and induces differentiation of U937 cells (EC50 = 2,000 pM); induces cell cycle arrest at the S phase and apoptosis in primary adenomatous and hyperplastic human parathyroid cells at 10 nM; increases bone calcium mobilization in chicks on a low calcium diet at 0.65 nmol/animal; stimulates calcium absorption in the intestines in a chick model of rickets induced by a vitamin D3-deficient diet
Cayman Chemical desbutyl LumefntrIn 10mg
An active metabolite of lumefantrine; active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 9 and 9.5 nM, respectively); inhibits the hERG potassium channel in HEK293 cells expressing the human channel (IC50 = 5.49 µM)
Cayman Chemical LIxIsenatIdeacetate 10mg
A GLP-1R agonist; binds to CHO-K1 cells expressing human GLP-1R (IC50 = 1.4 nM); inhibits Il-1β- and IFN-γ-induced apoptosis in INS-1 rat pancreatic β-cells at 100 pM; lowers blood glucose levels in an OGTT (ED50 = 0.021 nmol/kg) and decreases blood HbA1c levels in db/db mice
Cayman Chemical Buca javnca L M. Bucn D 10mg
A quassinoid with diverse biological activities; active against chloroquine-resistant P. falciparum (IC50 = 0.015 UG/ml); selectively inhibits the proliferation of PANC-1, SW 1990, and Capan-1 cancer cells over Hs68 fibroblasts (IC50s = 2.53, 5.21, 1.35, and >30 µM, respectively); protects against MPTP-induced motor impairments and dopaminergic neurodegeneration in a mouse model of Parkinson’s disease at 20 or 40 mg/kg; decreases carrageenan-induced paw inflammation in rats at 0.25 or 1 mg/kg
Cayman Chemical MyrIstoylCoenzyme AsodIum 10mg
A saturated acyl CoA; a substrate for N-myristoyltransferase during myristoylation; a substrate in the de novo synthesis of phosphatidylinositol
Cayman Chemical 2 4DImethylmethcathInonhy 10mg
A disubstituted analog of methcathinone; intended for research and forensic purposes
Cayman Chemical FludarabIn Phosphate 10mg
A prodrug form of fludarabine and 2-fluoro-ara-ATP; reduces viability of, and induces apoptosis in, N-Myc-overexpressing LASCPC-01 cells (IC50 = 17.67 µM); reduces N-Myc protein levels when used at 25 µM for at least 48 hours; reduces tumor volume in N-Myc-overexpressing 22Rv1-N-Myc and LASCPC-01, but not non-N-Myc-overexpressing 22Rv1, mouse xenograft models at 120 mg/kg; an inhibitor of SARS-CoV-2 RdRp (EC50 = 0.93 µM)
Cayman Chemical TenovIn-6hydrochlorIde 10mg
A analog of tenovin-1; elevates p53 activity in MCF-7 cells at 10 µM and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg
Cayman Chemical LY266097hydrochlorIde 10mg
A 5-HT2B receptor antagonist (Ki = 0.5 nM); selective for 5-HT2B over 5-HT2A and 5-HT2C receptors (Kis = 19.5 and 24.55 nM, respectively); reduces L5/L6 spinal nerve ligation-induced hind paw tactile allodynia in a rat model of neuropathic pain at an intrathecal dose of 100 nmol; reduces hyperlocomotion induced by cocaine in rats at 0.63 mg/kg
Cayman Chemical EHNAhydrochlorIde 10mg
A dual inhibitor of adenosine deaminase (IC50 = 1.2 μM in human red blood cells) and PDE2 (IC50s = 0.8 and 2 μM from human and pig myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet)
Cayman Chemical SalIdrosIde 10mg
A glycoside; scavenges DPPH and ABTS radicals (EC50s = 81.54 and 30.94 UG/ml, respectively, in cell-free assays); inhibits apoptosis and production of ROS induced by Aβ (23-35) in SH-SY5Y neuroblastoma cells at 50 and 100 µM; decreases infarct volume by 17.9% in a rat model of focal cerebral ischemia-reperfusion injury induced by MCAO at 12 mg/kg; increases survival and reduces plasma ALT, AST, TNF-α, and MDA levels in a mouse model of acetaminophen-induced liver injury
Cayman Chemical 11-deoxy ProstaglndIn E1 10mg
11-deoxy PGE1 is a synthetic analog of PGE1. EArly reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2.{1360,1026} However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC50 of 0.25 µM.{2120} 11-deoxy PGE1 also exhibits vasodepressor and bronchodilator responses in guinea pigs.{2217} 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The Ki values for binding to the murine EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.{6640}
Cayman Chemical ResorcInolnaphthaleIn 10mg
Increases the activity of angiotensin-converting enzyme 2 (ACE2) in vitro (EC50 = 19.5 μM)