Custom Peptides
Cayman Chemical on-8711dIcyclohexylamIn s 10mg
An EP1 receptor antagonist (Kis = 0.6 and 1.7 nM for human and mouse receptors, respectively, expressed in CHO cells); is selective for EP1 over EP2, EP3, and EP4 (Kis = >1,000, 67, and >1,000 nM, respectively, for mouse receptors expressed in CHO cells); inhibits PGE2-induced increases in intracellular calcium concentrations in cells expressing human or mouse EP1 (EC50s = 50 and 210 nM, respectively); reduces the incidence of squamous cell carcinoma and severe dysplasia induced by 4-nitroquinoline 1-oxide in a rat model of tongue carcinogenesis at 400 and 800 ppm in the diet
Cayman Chemical 2AmIno1methyl6phenylImId 10mg
A food-derived carcinogen; metabolized by CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts; chronic treatment (1 pM/L for 20 cycles) of MCF-10A cells induces anchorage-independent cell growth and reduces cellular dependence on growth factors; increases wild-type H-Ras gene and protein expression which activates ERK signaling, MMP-2 and MMP-9 protein expression, and NOX1-driven production of ROS in vitro; increases tumor formation in a murine breast cancer xenograft model; induces formation of colon tumors with β-catenin gene mutations that hyperactivate the Wnt signaling pathway in a CYP1A2 humanized rat model; increases the occurrence of atypical hyperplasias and carcinomas in the ventral prostate and seminal vesicles of rats
Cayman Chemical 1-O-AcetylbrItnIlacton 10mg
A sesquiterpene lactone with diverse biological activities; inhibits LPS-induced production of PGE2 and nuclear translocation of NF-κB in primary rat aorta VSMCs; inhibits VEGF-induced capillary tube formation in HUVECs at 5 and 10 µM; reduces tumor growth in an A549 mouse xenograft model at 12 mg/kg per day
Cayman Chemical GalactInolhydrate 10mg
An α-galactoside of inositol that serves as a galactosyl donor in the transglycosidase-catalyzed biosynthesis of the raffinose family; generated from myo-inositol and uridine diphosphate galactose in a galactosyltransferase-catalyzed reaction
Cayman Chemical DefensamIde 10mg
An SPHK1 activator; increases S1P levels in primary human keratinocytes but does not affect S1P lyase activity in the same cells at 100 µM; increases protein levels of LL-37 in primary human keratinocytes at 100 µM; inhibits invasion of S. aureus into murine skin ex vivo; has been used as an intermediate in the synthesis of sinuxylamide A as well as compounds with anticancer and antibacterial activities
Cayman Chemical 17phenl trInor ProstglndI 10mg
An F-series PG analog in which the C-1 carboxyl group has been modified to an N-diethyl amide; dialkyl amides such as a 17-p-PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids
Cayman Chemical DImethylfraxetIn 10mg
A coumarin with anti-inflammatory activity; reduces TPA-induced auricular edema in mice at 1 mg/ear
Cayman Chemical TatCIRPtrIfluoroACTAte sa 10mg
A peptide inhibitor of the MD-2-CIRP protein-protein interaction; binds to MD-2 and disrupts the interaction between MD-2 and CIRP in co-immunoprecipitation assays; reduces infarct volume in a mouse model of MCAO-induced stroke at 10 and 20 mg/kg; reduces infarct volume and decreases the time to pick up and withdraw food with the stroke-affected arm in a rhesus monkey model of thrombosis-induced stroke
Cayman Chemical CnrtInIbhydrochlorIde 10mg
An irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively; inhibits the proliferation of various tumor cells
Cayman Chemical FerroLOXIN-1 10mg
A 15-LO-2/PEBP1 and ferroptosis inhibitor; selectively inhibits the peroxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by the 15-LO-2/PEBP1 complex over 15-LO-2 alone in cell-free assays at 0.25 µM; inhibits RSL3-induced ferroptosis in primary human bronchial epithelial cells (IC50 = 84 nM); increases survival in a mouse model of total body irradiation at 25 mg/kg
Cayman Chemical CephalomnIn 10mg
A taxane diterpenoid; inhibits calcium-induced microtubule depolymerization in vitro; increases vincristine accumulation in multidrug-resistant 2780AD ovarian cancer cells
Cayman Chemical PIclIdenoson 10mg
An adenosine A3 receptor agonist (Ki = 1.7 nM); selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively); reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion at 100 UG/kg; reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and the number of lung metastases in a model of metastatic murine melanoma; reduces colonic inflammatory cell infiltration and damage in a mouse model of DSS-induced colitis and in in IL-10-/- mice at 1 and 3 mg/kg
Cayman Chemical 11-deoxy ProstaglndIn F2a 10mg
11-deoxy PGF2α is a synthetic analog of PGF2α. It is a more potent agonist than PGF2α at inducing smooth muscle contractions of rabbit aorta, dog saphenous vein, and guinea pig trachea.{2260} It is approximately 20% less potent than U-46619.{2260}
Cayman Chemical EthopropazInhydrochlorIde 10mg
A BChE inhibitor (IC50 = 15.14 µM in human erythrocyte lysates); selective for BChE over AChE at 500 µM; binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively; decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with ZM 241395 at 0.232 mg/kg; reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation at 20 and 30 mg/kg
Cayman Chemical 3BromotyrosIntrIfluoroace 10mg
A product of protein oxidation; a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo